abstract：:It has been reported that natural helper cells, which are a non-T, non-B innate lymphoid cell type expressing c-Kit and ST2, mediate influenza-induced airway hyper-reactivity by producing substantial IL-13. However, little is known about natural helper cells for the development of RSV-induced airway inflammation, part...

journal_title：International immunopharmacology

authors： Liu J,Wu J,Qi F,Zeng S,Xu L,Hu H,Wang D,Liu B

更新日期：2015-09-01 00:00:00

abstract：:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stres...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Total glucosides of paeony (TGP) have been confirmed to exert anti-inflammatory and hepatoprotective effects. Methotrexate (MTX) and Leflunomide (LEF) combination has a better efficacy in the treatment of active rheumatoid arthritis (RA), but hepatotoxicity was observed. In this study, we investigated the eff...

journal_title：International immunopharmacology

authors： Xiang N,Li XM,Zhang MJ,Zhao DB,Zhu P,Zuo XX,Yang M,Su Y,Li ZG,Chen Z,Li XP

更新日期：2015-09-01 00:00:00

abstract：:This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14 days of age) were randomly allotted into either 0 (control group) or 40 mg/kg soy isoflavone (ISO) supplementation group. On days 7 and 14, half of th...

journal_title：International immunopharmacology

authors： Zhu C,Wu Y,Jiang Z,Zheng C,Wang L,Yang X,Ma X,Gao K,Hu Y

更新日期：2015-09-01 00:00:00

abstract：:Here, we investigated the role of LXRα in capsaicin mediated anti-inflammatory effects. Results revealed that capsaicin inhibits LPS-induced IL-1β, IL-6 and TNF-α production in a time- and dose-dependent manner. Moreover, capsaicin increases LXRα expression through PPARγ pathway. Inhibition of LXRα activation by siRNA...

journal_title：International immunopharmacology

authors： Tang J,Luo K,Li Y,Chen Q,Tang D,Wang D,Xiao J

更新日期：2015-09-01 00:00:00

abstract：:Cisplatin is a widely used antineoplastic drug, but its clinical usefulness is limited due to dose dependent nephrotoxicity. Nordihydroguaiaretic acid (NDGA) is a natural compound with broad pharmacological properties like antioxidant, anti-inflammatory and anticancer activity. The present study was undertaken to eval...

journal_title：International immunopharmacology

authors： Mundhe NA,Kumar P,Ahmed S,Jamdade V,Mundhe S,Lahkar M

更新日期：2015-09-01 00:00:00

abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

journal_title：International immunopharmacology

authors： Majdalawieh AF,Fayyad MW

更新日期：2015-09-01 00:00:00

abstract：:The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, apoptosis, and angiogenesis. We identified dihydrotanshinone I as an inhibitor of NF-κB activation through our research on Salvia miltiorrhiza Bunge. In this study, we found that dihydrotanshinone...

journal_title：International immunopharmacology

authors： Wang F,Ma J,Wang KS,Mi C,Lee JJ,Jin X

更新日期：2015-09-01 00:00:00

abstract：:The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

journal_title：International immunopharmacology

authors： Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

更新日期：2015-09-01 00:00:00

abstract：:With the introduction of biological agents, over the last two decades treatment prospects in many medical fields including Rheumatology have experienced an exciting revolution. The advent of biological therapy for specifically rheumatic diseases has provided more effective control of both the underlying disease, and s...

journal_title：International immunopharmacology

authors： Lie G,Sciascia S,Cuadrado MJ

更新日期：2015-08-01 00:00:00

abstract：:Hypercapnia is known to have immunoregulatory effects within the lung. Cell culture systems demonstrate this in both macrophages and alveolar cell lines, suggesting that the alveoli are affected by changes in CO2 levels. We hypothesized that hypercapnia would also modulate human bronchial epithelial cell immune respon...

journal_title：International immunopharmacology

authors： Schneberger D,Cloonan D,DeVasure JM,Bailey KL,Romberger DJ,Wyatt TA

更新日期：2015-07-01 00:00:00

abstract：:Platycodin D (PLD) is the major triterpene saponin in the root of Platycodon grandiflorum (Jacq.) with various pharmacological activities. The purpose of the present study was to evaluate the protective effects and possible mechanisms of PLD on acute lung injury (ALI) both in vivo and in vitro. In vivo, we used two AL...

journal_title：International immunopharmacology

authors： Tao W,Su Q,Wang H,Guo S,Chen Y,Duan J,Wang S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:This study investigated some T helper cytokines' association with different ANA positive sera. METHODS:Sera of 53 ANA-positive subjects (11 were stained of homogeneous pattern, 12 of speckled particle pattern, 9 of nucleolar pattern, 15 of centromere pattern, and 6 of the peripheral nuclear type) were collec...

journal_title：International immunopharmacology

authors： Hu J,Zhang Y,Liu X,Wei L,Zhang D

更新日期：2015-02-01 00:00:00

abstract：:Rubi Fructus, a traditional Chinese medicine, was considered as an anti-inflammatory agent in folk medicine. In the present study, we investigated the signalling pathways involved in the anti-inflammatory effects of goshonoside-F5 (GF5), isolated from Rubi Fructus, in peritoneal macrophages and examined its therapeuti...

journal_title：International immunopharmacology

authors： He JM,Chen SC,Li RP,Yuan LX,Bao JM,Guo ML

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVES:Bone and lung involvement are two major causes of morbidity in Gaucher disease (GD). The soluble form of CD163 (sCD163) is a valuable diagnostic biomarker for monitoring diseases with increased macrophage activation. We determined sCD163 levels in 30 children and adolescence with GD compared with 30 healthy ...

journal_title：International immunopharmacology

authors： Adly AAM,Ismail EAR,Ibraheem TM

更新日期：2015-02-01 00:00:00

abstract：:Coronary atherosclerotic heart disease (CHD) is currently regarded as a chronic inflammatory disease. The inflammatory cytokine neopterin (NP) is a new predictor of the stable type of atherosclerotic plaque, and this study focused on the relationship between neopterin, Gensini score and high-sensitivity C-reactive pro...

journal_title：International immunopharmacology

authors： Lyu Y,Jiang X,Dai W

更新日期：2015-02-01 00:00:00

abstract：:Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Watanabe K

更新日期：2014-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is considered to be primarily associated with loss of motor function and leads to the activation of diverse cellular mechanisms in the central nervous system to attempt to repair the damaged spinal cord tissue. Higenamine (HG) (1-[(4-hydroxyphenyl) methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-di...

journal_title：International immunopharmacology

authors： Zhang Z,Li M,Wang Y,Wu J,Li J

更新日期：2014-12-01 00:00:00

abstract：:In the course of a search for anti-neuroinflammatory metabolites from marine fungi, aurantiamide acetate (1) was isolated from marine-derived Aspergillus sp. as an anti-neuroinflammatory component. Compound 1 dose-dependently inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in BV2 microglial c...

journal_title：International immunopharmacology

authors： Yoon CS,Kim DC,Lee DS,Kim KS,Ko W,Sohn JH,Yim JH,Kim YC,Oh H

更新日期：2014-12-01 00:00:00

abstract：:Prostaglandin E2 (PGE2), a very potent lipid mediator produced from arachidonic acid (AA) through the action of cyclooxygenase (COX) enzymes, is implicated in the regulation of dendritic cell (DC) functions such as differentiation ability, cytokine-producing capacity, Th-cell polarizing ability, migration and maturati...

journal_title：International immunopharmacology

authors： Jia XY,Chang Y,Sun XJ,Dai X,Wei W

更新日期：2014-11-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) has been identified to be a critical mediator of severe sepsis. Ketamine has been shown to reduce sepsis-induced pathological complications. These effects are because of the reduced expression and release of several inflammatory mediators. However, whether ketamine affects the express...

journal_title：International immunopharmacology

authors： Zhang Z,Zhang L,Zhou C,Wu H

更新日期：2014-11-01 00:00:00

abstract：:Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a critical role in initiating immunoinflammatory responses. In this study, we generated recombinant mouse IL-1β and anti-mouse IL-1β polyclonal antibodies to examine the effect of IL-1β on experimental autoimmune uveoretinitis (EAU), a mouse model ...

journal_title：International immunopharmacology

authors： Zhao R,Zhou H,Zhang J,Liu X,Su SB

更新日期：2014-10-01 00:00:00

abstract：:Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on...

journal_title：International immunopharmacology

authors： Gu L,Deng WS,Liu Y,Jiang CH,Sun LC,Sun XF,Xu Q,Zhou H

更新日期：2014-10-01 00:00:00

abstract：:The possible onset of Cytokine Release Syndrome (CRS) is an important consideration in the development of monoclonal antibody (mAb) therapeutics. In this study, several machine learning approaches are used to analyze CRS data. The analyzed data come from a human blood in vitro assay which was used to assess the potent...

journal_title：International immunopharmacology

authors： Xiong F,Janko M,Walker M,Makropoulos D,Weinstock D,Kam M,Hrebien L

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:A new strategy of adoptive and passive immunotherapy involves combining dendritic cells (DCs) with a subset of natural killer T lymphocytes termed cytokine-induced killer (CIK) cells. The objective of this systematic review and meta-analysis was to evaluate the safety and efficacy of DC-CIK therapy vs. placebo,...

journal_title：International immunopharmacology

authors： Chen R,Deng X,Wu H,Peng P,Wen B,Li F,Li F

更新日期：2014-10-01 00:00:00

abstract：:The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own...

journal_title：International immunopharmacology

authors： Ge L,Hoa NT,Wilson Z,Arismendi-Morillo G,Kong XT,Tajhya RB,Beeton C,Jadus MR

更新日期：2014-10-01 00:00:00

abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

journal_title：International immunopharmacology

authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

更新日期：2014-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis and limited methods to predict patient survival. Immune cells infiltrating tumors are known to impact tumor progression. Here, we analyzed the phenotype and function of dendritic cells (DCs), and the frequency of IL-10-producing regulatory B c...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Li P,Wu H,Lu J,Wei W

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Chondrocytes are one of the main cell types involved in rheumatoid inflammation, releasing mediators which add to cartilage destruction, bone damage and consequently disability. Current evidence suggests that serotonin 5-HT(3) receptor antagonists (5-HT(3)RA) show anti-inflammatory and antioxidant properties...

journal_title：International immunopharmacology

authors： Stratz C,Anakwue J,Bhatia H,Pitz S,Fiebich BL

更新日期：2014-09-01 00:00:00

abstract：:The frequency of different subsets of CD4(+)CXCR5(+) TFH cells and serum cytokine levels were analyzed in a total of 14 patients with newly diagnosed hepatitis B virus-associated membranous nephropathy (HBV-MN), 12 individuals with immune-tolerant HBV infection (HBV-IT) and 12 healthy controls (HC). Serum cytokine lev...

journal_title：International immunopharmacology

authors： Liu Y,Zhao P,Qu Z,Ayana DA,Jiang Y

更新日期：2014-09-01 00:00:00

abstract：:The immune system is the body's natural defense system against invading pathogens. It protects the body from infection and works to communicate an individual's well-being through a complex network of interconnected cells and cytokines. This system is an associated host defense. An uncontrolled immune system has the po...

journal_title：International immunopharmacology

authors： Szablewski L

更新日期：2014-09-01 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, has been reported to have a protective effect against lipopolysaccharide (LPS)-induced mastitis. However, the underlying molecular mechanisms are not well understood. The aim of this study was to investigate the molecular mechanisms of e...

journal_title：International immunopharmacology

authors： Yang Z,Zhou E,Wei D,Li D,Wei Z,Zhang W,Zhang X

更新日期：2014-08-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) mediate tumor-associated immune suppression in both cancer patients and tumor-bearing animals. Reduction or elimination of MDSCs reduces the rate of tumor progression and improves cancer therapies that employ mechanisms of immunity. Here we show that baccatin III, which is the ...

journal_title：International immunopharmacology

authors： Lee YH,Lee YR,Park CS,Im SA,Song S,Hong JT,Whang BY,Kim K,Lee CK

更新日期：2014-08-01 00:00:00

abstract：:The effects of intravenous immunoglobulin (IVIG) products are being evaluated in Alzheimer's disease (AD) patients. IVIG contains antibodies to tau protein, the main constituent of neurofibrillary tangles (NFTs). Tau has microtubule binding domain (MBD) repeats which are thought to be necessary for its aggregation, a ...

journal_title：International immunopharmacology

authors： Smith LM,Coffey MP,Loeffler DA

更新日期：2014-08-01 00:00:00

abstract：:The objective of the current study was to retrospectively investigate the efficacy of adaptive transfer of natural killer (NK) and cytotoxic T lymphocytes mixed effector (NKTm) cells in non-small cell lung cancer (NSCLC) patients in comparison to a control group of NSCLC patients. NKTm cells were obtained by ex vivo e...

journal_title：International immunopharmacology

authors： Zhang G,Zhao H,Wu J,Li J,Xiang Y,Wang G,Wu L,Jiao S

更新日期：2014-08-01 00:00:00

abstract：:Acute liver failure is characterized by the sudden loss of hepatic function and a high mortality. SKLB010, a derivative of thiazolidinediones, has been proved to be effective in protecting mice from acute liver failure caused by concanavalin A and carbon tetrachloride in our previous work. The purpose of the current s...

journal_title：International immunopharmacology

authors： Xie C,Jingjing W,Li X,Zeng F,Ma L,Li C,Wei Z,Peng A,Chen L

更新日期：2014-08-01 00:00:00

abstract：:Oral contraceptives (OC) may cause intrahepatic cholestasis or increase a pre-established liver damage. OC effects on hepatic injury biochemical markers remain contradictory and the role of cytokines in those processes is fairly unknown. Two doses, simple or double, of the OC combination ethinylestradiol/norgestrel we...

journal_title：International immunopharmacology

authors： Fernández-Martínez E,Pérez-Soto E,González-Hernández C,Ortiz MI,Pérez-Álvarez V,Muriel P,Shibayama M

更新日期：2014-07-01 00:00:00

abstract：:A Gram-positive bacterium, Staphylococcus aureus is known to be one of the major pathogenic bacteria responsible for causing bovine mastitis. Among the various cell wall components of S. aureus, lipoteichoic acid (LTA) and peptidoglycan (PGN) are closely associated with inflammatory responses. However, the role of LTA...

journal_title：International immunopharmacology

authors： Im J,Lee T,Jeon JH,Baik JE,Kim KW,Kang SS,Yun CH,Kim H,Han SH

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Endothelin1 (EDN1) is well established marker of inflammation. The functions of EDN1 are mediated mainly by endothelin receptors type A (EDNRA). The etiopathogenesis of Hashimoto's thyroiditis (HT) remains still elusive although the role of chronic inflammation and subsequent endothelial dysfunction has been es...

journal_title：International immunopharmacology

authors： Aydin AF,Vural P,Oruç ÇU,Doğru-Abbasoğlu S,Özderya A,Karadağ B,Uysal M

更新日期：2014-07-01 00:00:00

abstract：:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural e...

journal_title：International immunopharmacology

authors： Li Z,Ji H,Song X,Hu J,Han N,Chen N

更新日期：2014-05-01 00:00:00